25 patients with schizophrenia with pronounced negative symptoms during psychotic remission and 24 healthy controls were included in this study. Results provide evidence for impaired model-free reward prediction influence as a mechanism for negative symptoms in schizophrenia as well as for reduced associative striatum dopamine and executive dysfunction as relevant factors. Data suggest potential treatment targets for patients with schizophrenia and pronounced negative symptoms.
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Brandl, F., Knolle, F., Avram, M., Leucht, C., Yakushev, I., Priller, J., Leucht, S., Ziegler, S., Wunderlich, K., & Sorg, C. (2022). Negative symptoms, striatal dopamine, and model-free reward decision-making in schizophrenia. Brain : a journal of neurology, awac268. Advance online publication. https://doi.org/10.1093/brain/awac268