In this new study, we identified two transdiagnostic, neuroanatomically informed clusters that are clinically and biologically distinct and challenge current diagnostic boundaries in recent-onset mental health disorders. These findings may help to transdiagnostically understand the etiology of patients with poor outcomes and improve the development of stratified treatments.
For more information see:
Lalousis, P. A., Schmaal, L., Wood, S. J., Reniers, R., Barnes, N. M., Chisholm, K., Griffiths, S. L., Stainton, A., Wen, J., Hwang, G., Davatzikos, C., Wenzel, J., Kambeitz-Ilankovic, L., Andreou, C., Bonivento, C., Dannlowski, U., Ferro, A., Lichtenstein, T., Riecher-Rössler, A., Romer, G., … PRONIA Consortium (2022). Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes. Biological psychiatry, S0006-3223(22)01156-8. Advance online publication. https://doi.org/10.1016/j.biopsych.2022.03.021