Pronounced orthostatic hypotension in GBA-related Parkinson’s disease

Patients with Parkinson’s disease (PD) carrying variants in the Glucocerebrosidase (GBA) gene (GBA-PD) suffer from orthostatic symptoms more frequently than idiopathic PD patients (IPD). Systematic measurements of the blood pressure have not yet been performed. In the present study, a prospective analysis of 33 GBA-PD and 313 IPD patients was carried out. Systolic blood pressure upon changing from the supine to the upright position dropped more strongly in GBA-PD compared to IPD patients. Diastolic blood pressure and heart rate did not differ between groups. Our new study (Usnich et al., 2022) provides further evidence for a pronounced involvement of the autonomic nervous system in GBA-PD.

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Usnich, T., Hanssen, H., Lohmann, K., Lohse, C., Klein, C., Kasten, M., Brüggemann, N., & EPIPARK Study Group (2022). Pronounced Orthostatic Hypotension in GBA-Related Parkinson’s Disease. Journal of Parkinson’s disease, 10.3233/JPD-223197. Advance online publication.

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